Extracellular Vesicles (EV)
Extracellular Vesicles are classified into three types of the sizes (Small EVs, Microvesicles(100-1000nm) and Apoptotic Bodies(1000-5000nm). Especially, the small EVs(30-100nm) including exosomes, we interested in, carry marker of cells of origin and have specialized functions in physiological processes, from coagulation and intercellular signaling to waste management.[1] Consequently, there is a growing interest in clinical applications as biomarkers and therapies alike.[2]
In many cases, as shown above, bio molecules can be simply classified according to their size. Focused on the fact, we design the size-based separation method to purify the molecules which researchers need.
Reference
[1] Classification, functions, and clinical relevance of extracellular vesicles(July 2012). Pharmacological Reviews. 64 (3): 676–705.
[2] Urinary extracellular vesicle biomarkers in urological cancers: From discovery towards clinical implementation”(June 2018). The International Journal of Biochemistry & Cell Biology. 99: 236–256.